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■ Synthesis of Macrocyclic Dimer of Cyclic Hexaoxazole and Examination of Its Interaction with Telomeric Oligonucleotide

Keisuke Iida, Gen Tsubouchi, Takahiro Nakamura, and Kazuo Nagasawa*

*Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Koganei, Tokyo 184-8588, Japan

Abstract

A telomestatin-type macrocyclic dimer of cyclic hexaoxazole, termed 6OTD-dimer (5), was synthesized as a new G-quadruplex (G4) ligand by incorporating a second linker into L2H2-6OTD-dimer (3). This macrocyclic-type G4 ligand (5) was found to interact with telomeric oligonucleotide, and stabilized telomeric G4 structure more effectively than did the corresponding non-macrocyclic L2H2-6OTD analog 4.