Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Special issue | Vol 88, No. 2, 2014, pp.1287-1298
Published online, 28th August, 2013
DOI: 10.3987/COM-13-S(S)97
Synthesis of Macrocyclic Dimer of Cyclic Hexaoxazole and Examination of Its Interaction with Telomeric Oligonucleotide

Keisuke Iida, Gen Tsubouchi, Takahiro Nakamura, and Kazuo Nagasawa*

*Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Koganei, Tokyo 184-8588, Japan


A telomestatin-type macrocyclic dimer of cyclic hexaoxazole, termed 6OTD-dimer (5), was synthesized as a new G-quadruplex (G4) ligand by incorporating a second linker into L2H2-6OTD-dimer (3). This macrocyclic-type G4 ligand (5) was found to interact with telomeric oligonucleotide, and stabilized telomeric G4 structure more effectively than did the corresponding non-macrocyclic L2H2-6OTD analog 4.