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Short Paper | Special issue | Vol 88, No. 2, 2014, pp.1501-1509
Published online, 4th September, 2013
DOI: 10.3987/COM-13-S(S)49
■ Constituents from the Rhizomes of Curcuma comosa and Their Wnt Signal Inhibitory Activities

Rolly G. Fuentes, Kazufumi Toume, Midori A. Arai, Takashi Koyano, Thaworn Kowithayakorn, and Masami Ishibashi*

*Department of Natural Products Chemistry, Graduate School of Pharmaceutical Science, Chiba University, 1-8-1 Inohana, Chuo, Chiba, Japan

Abstract

Activity-guided fractionation of the Curcuma comosa rhizome MeOH extract that inhibited Wnt signal activity led to the characterization of two new diarylheptanoids (1 and 2) together with six known diarylheptanoids (3-8) and two known sesquiterpenoids (9 and 10). Their structures were identified by 1D and 2D NMR, HRESIMS, optical rotation, and chemical evidences. Compounds 1 and 8 exhibited dose-dependent inhibitory activity against β-catenin/TCF transcriptional activity.