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Paper | Special issue | Vol 88, No. 1, 2014, pp.275-286
Published online, 10th June, 2013
DOI: 10.3987/COM-13-S(S)13
Palladium-Catalyzed Direct Arylation and Alkenylation of 3-(Indol-3-yl)propionic Acids through C–H Bond Cleavage

Daisuke Takeda, Koji Hirano, Tetsuya Satoh,* and Masahiro Miura*

*Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan


The palladium-catalyzed direct arylation of 3-(indol-3-yl)propionic acids with aryl bromides proceeds through C–H bond cleavages to give C2-arylated product in good yields. The C2-alkenylation of the substrates can also be performed smoothly under appropriate oxidative conditions.