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Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
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January 13, 2023
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Short Paper | Regular issue | Vol 87, No. 4, 2013, pp.861-867
Published online, 20th February, 2013
Published online, 20th February, 2013
DOI: 10.3987/COM-13-12667
■ Aculeatusquinones A-D, Novel Metabolites from the Marine-Derived Fungus Aspergillus aculeatus
Li Chen,* Wei-Wei Zhang, Qiu-Hong Zheng, Qin-Ying Liu, Ping Zhong, Xiao Hu, Zhe-Xiang Fang, and Qi-Qing Zhang*
*Institute of Biomedical and Pharmaceutical Technology & College of Chemistry and Chemical Engineering, Fuzhou University, No. 523, Gongye Road, Fuzhou City, 350002, China
Abstract
Four new aculeatusquinones A–D (1–4) and five known compounds, (5aS,6S,7S)-3,7-dihydroxy-6-methoxy-1,4,6,9-tetramethyl-6,7-dihydro-5aH-dibenzo[b,e][1,4]dioxepine-8,11-dione (5), 3,8-dihydroxy-1,4,6,9-tetramethyldibenzo[b,e][1,4]dioxepin-11-one (6), 4-O-demethylbarbatic acid (7), atraric acid (8), and 2,5-dimethyl-1,3-benzenediol (9), were isolated from the marine-derived fungus Aspergillus aculeatus. The structures of the new compounds were elucidated by spectroscopic methods, including one- and two-dimensional NMR and high-resolution mass spectrometric analyses. Two new compounds (2 and 4) showed cytotoxic effects on the HL-60, K562, and A-549 cell lines, with IC50 values ranging from 5.4 μM to 76.1 μM.
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