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Short Paper | Regular issue | Vol 87, No. 4, 2013, pp.853-860
Published online, 22nd February, 2013
DOI: 10.3987/COM-13-12668
A MILD AND CONVENIENT ONE-POT SYNTHESIS OF 4-ARYL-N-OH-HANTZSCH ESTERS

Chun-Bao Miao,* Chun-Ping Dong, Yan-Hong Wang, Hai-Tao Yang, Qi Meng, Shu-Jiang Tu, and Xiao-Qiang Sun*

*School of Petrochemical Engineering, Changzhou University, Gehu Road 1#, Wujin Area, Changzhou City, China

Abstract

A general methodology to prepare a series of 4-Aryl-N-OH Hantzsch esters was developed. The key factor is to control the first-step of Michael addition at 0 °C. The method was practical to produce symmetrical and unsymmetric N-OH-Hantzsch esters in moderate yield. This class of compounds might have use in medicinal and material science.