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Paper | Regular issue | Vol 87, No. 3, 2013, pp.591-598
Published online, 4th February, 2013
DOI: 10.3987/COM-12-12651
Synthetic and Theoretical Approach towards Spirothiazolidinone Systems

Johnson George, Saurabh Singh, Rahul Joshi, Pushpa Pardasani, and Ramchand T. Pardasani*

*Department of Chemistry, Central University of Rajasthan, Bandarsindri, Distt. Ajmer-305802, India

Abstract

A convenient synthesis of spirothiazolidinones by nucleophilic cyclocondensation of intermediate imine with mercaptoacetic acid is described. Computational studies have been performed to substantiate the proposed mechanism as well as to ascertain transition state of the system.