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Short Paper | Regular issue | Vol 87, No. 3, 2013, pp.657-663
Published online, 18th January, 2013
DOI: 10.3987/COM-12-12646
Synthesis of Pyrazoles through Copper-Catalyzed Three-Component Coupling of Aldehydes, Alkynes, and p-Toluenesulfonylhydrazide

Feng Wu, Lu Hao, and Zhuang-ping Zhan*

*College of Chemistry and Chemical Engineering, Department of Chemistry, Xiamen University, 422 Siming Nanlu, Xiamen, Fujian 361005, China


A convenient one-pot synthesis of 3,5-disubstitued 1H-pyrazoles through copper-catalyzed three-component of aldehydes, alkynes, and para-tolylsulfonohydrazide has been developed. This method provides a flexible and rapid route to 3,5-disubstituted 1H-pyrazoles.