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Short Paper | Regular issue | Vol 87, No. 2, 2013, pp.417-422
Published online, 26th December, 2012
DOI: 10.3987/COM-12-12633
Melanogenesis-Modulating Diketopiperazine Derivatives from Hypocrea spp.

Tetsuro Kawabata,* Chiaki Uchida, Hikaru Kato, Tomoyuki Tsubata, Fumihide Takano, and Tomihisa Ohta

*School of Pharmacy and Pharmaceutical Sciences, Kanazawa University, Kakuma, Kanazawa, Ishikawa 920-1192, Japan


A new dioxopiperazine derivative, hypocreasin (1), and five known (26) compounds were isolated from the fungus Hypocrea spp. The structure of 1 was determined by 1D/2D NMR and MS spectroscopic analyses. Compound 2 increased melanogenesis but 3 inhibited it in cultured murine melanoma B16F1 cells.