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Paper | Regular issue | Vol 87, No. 2, 2013, pp.341-356
Published online, 12th December, 2012
DOI: 10.3987/COM-12-12625
Synthetic Utility of Ethylidenethiosemicarbazide: Synthesis and Anticancer Activity of 1,3-Thiazines and Thiazoles with Imidazole Moiety

Sobhi M. Gomha, Sayed M. Riyadh,* Ikhlass M. Abbas, and Mohammed A. Bauomi

*Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt


Reactions of ethylidenethiosemicarbazide 3 with DMAD 4 or substituted methylenemalononitriles 8 gave thiazolidin-4-one 6 or 1,3-thiazine derivatives (10, 11), respectively. Also, treatment of 3 with hydrazonoyl halides 12a-i, α-haloketones 15a-d, and chloroacetic acid 18 afforded the corresponding arylazothiazoles 14a-i, thiazoles 17a-d, and thiazolin-4-one derivative 20, respectively. The structures of the synthesized products were confirmed by IR, 1H NMR, 13C NMR and mass spectral techniques. The anticancer activity of the selected products against the colon carcinoma cell line (HCT-116) was determined and the results revealed promising activity of compound 6.