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Paper | Regular issue | Vol 87, No. 1, 2013, pp.79-89
Published online, 28th November, 2012
DOI: 10.3987/COM-12-12610
Preparation of 6-Ethynylpteridine Derivatives by Sonogashira Coupling

Winston Nxumalo* and Andrew Dinsmore

*Department of Chemistry, University of Limpopo, Private Bag X 1106, Sovenga 0727, South Africa


Sonogashira coupling of 6-sulfonyloxypteridine with various acetylenes is reported. Hydrolysis of the protecting groups with 1M NH3 gave the 6-subustituted 2,4-diaminopteridine while hydrolysis with 1M NaOH gave the 6-subsituted pterin.