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■ Three New Iridoid Compounds from Swertia cincta Burkill

Jin Yang, Feiyan Huang, Yongfu Zhou, Wei Liu, Ping Yi, and Ganpeng Li*

*Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Jingming South Road, Chenggong New District, Kunming, Yunnan 650500, China

Abstract

Three new iridoid compounds, 3,4,5,6-tetrahydro-8-hydroxy- 6-(hydroxymethyl)pyrano[3,4-c]pyran-1(8H)-one (1), 3,4,5,6-tetrahydro-8-hydroxy-6-methylpyrano[3,4-c]pyran-1(8H)-one (2), 5,6-dihydro-4-(1,3-dihydroxybutan-2-yl)-3-(hydroxymethyl)pyran-2-one (3), named swercinctolides A, B and C, were isolated from the 80% methanol extract of the whole plant of Swertia cincta Burkill, which is a traditional medicine in China. Their structures were defined on the basis of spectral evidences. Compounds 1, 2 and 3 showed TMV (Tobacco Mosaic Virus) inhibitory activity.