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Paper | Regular issue | Vol 85, No. 8, 2012, pp.1975-1986
Published online, 26th June, 2012
DOI: 10.3987/COM-12-12515
Synthesis of Pyridine-2,6-bis-((E)-2-benzylidene-3-oxopropanenitrile) and Its Behavior towards Nitrogen Binucleophiles

Korany A. Ali*

*Department of Applied Organic Chemistry, National Research Center, Dokki, Cairo 12622, Egypt

Abstract

Several new pyrazole, isoxazole and pyrimidine derivatives attached to pyridine ring at 2,6-positions have been synthesized by the reactions of the versatile multifunctional unreported pyridine-2,6-bis((E)-2-benzylidene-3-oxopropanenitrie) (2a) with several nitrogen binucleophiles. A novel one-pot three-component reaction of an aldehyde, pyridine-2,6-bis(3-oxopropanenitrile) (1) and electron-rich heterocyclic amines including [3-phenyl-1H-pyrazol-5-amine (12) and 2-aminobenzimedazole (16)] in DMF have been described.