Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Short Paper | Regular issue | Vol 85, No. 7, 2012, pp.1721-1726
Published online, 1st June, 2012
DOI: 10.3987/COM-12-12499
Convenient Synthesis of 5,7-Dichlorothiazolo[5,4-d]pyrimidine

Lianhe Shu,* Lady Mae Alabanza, and Chen Gu

*Process Research and Synthesis, Pharma Research and Early Development (pRED), Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, U.S.A.


A convenient synthesis of 5,7-dichlorothiazolo[5,4-d]pyrimidine is reported. The condensation of ethyl isocyanoacetate and ethoxycarbonyl isothiocyanate selectively gave the key 5-aminothiazole intermediate in high yield under mild conditions. This intermediate was then converted to the target product in three steps.