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Paper | Regular issue | Vol 85, No. 7, 2012, pp.1615-1628
Published online, 14th May, 2012
DOI: 10.3987/COM-12-12489
Highly Efficient Synthesis of 3,4-Dihydro-2(1H)-quinolinone Derivatives under Microwave Heating

Xiao-Tong Zhu, Qiu-Yun Li, Bo Jiang,* and Shu-Jiang Tu*

*School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Gree Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Jiangsu 221116, China


A sequential three-component reaction of aromatic aldehydes with aromatic amine, and Meldrum’s acid in EtOH under microwave irradiation has been developed. In this one-pot reaction, a series of 3,4-dihydro-2(1H)-quinolinone derivatives were synthesized with high chemical yields. The present green synthesis shows several advantages including operational simplicity and fast reaction rate, which makes it a useful and attractive process for library generation for drug discovery.