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Paper | Regular issue | Vol 85, No. 8, 2012, pp.1913-1923
Published online, 21st June, 2012
DOI: 10.3987/COM-12-12483
Synthesis of Some New Pyridine-2,6-bis-heterocycles

Korany A. Ali, Mohamed A. Elsayed, and Ahmad M. Farag*

*Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt


The versatile multifunctional hitherto unreported pyridine-2,6-bis[ethyl 2-(N,N-dimethylamino)methylene-3-oxopropanoate] (2) was prepared by the reaction of pyridine-2,6-bis(ethyl 3-oxopropanoate) (1) with 1,1-dimethoxytrimethylamine. Several new pyrazole, isoxazole, pyrimidine, pyrazolo[1,5-a]pyrimidine, and imidazo[1,2-a]pyrimidine derivatives attached to pyridine ring at 2,6-positions have been synthesized by the reactions of the enaminone 2 with the appropriate nitrogen binucleophiles.