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Short Paper | Regular issue | Vol 85, No. 6, 2012, pp.1457-1463
Published online, 2nd May, 2012
DOI: 10.3987/COM-12-12479
Improved Synthesis of 1-Oxo-1,2,3,4-tetrahydroacridine-9-carboxylic Acids from Isatins and 1,3-Cyclohexanedione

Qinghua Lv, Lizhen Fang,* Chenjuan Lu, and Pengfei Wang

*College of Pharmacy, Xinxiang Medical University, Xinxiang, Henan 453003, China


An improved protocol for the preparation of 1-oxo-1,2,3,4-tetrahydroacridine-9-carboxylic acid derivatives via Pfitzinger condensation under acidic conditions is described, it provides a simple one-pot synthetic method for some useful 1-oxo-1,2,3,4-tetrahydroacridine-9-carboxylic acids which could not be synthesized successfully by Pfitzinger reactions under usual conditions using the corresponding isatins and 1,3-diketones. All the synthesized compounds are characterized by spectral data.