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Paper | Regular issue | Vol 85, No. 9, 2012, pp.2173-2195
Published online, 10th July, 2012
DOI: 10.3987/COM-12-12473
Direct Halogenation Reactions in 2,3-Dihydro-4(1H)-quinazolinones

Fanny A. Cabrera-Rivera, Claudia Ortíz-Nava, Perla Román-Bravo, Marco A. Leyva, and Jaime Escalante*

*Chemical Research Center, Morelos Autonomous State University, Av. Universidad No. 1001, Col. Chamilpa, C. P. 62210, Cuernavaca-Morelos, Mexico, Mexico


Reaction of 2,3-dihydro-4(1H)-quinazolinones with NBS, Br2/Et3N and NCS yields 6,8-Br/Cl-2,3-dihydro-4(1H)-quinazolinones with moderate to good yield. The method does not require a catalyst and offers extremely short reaction time.