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Paper | Regular issue | Vol 85, No. 6, 2012, pp.1393-1404
Published online, 27th April, 2012
DOI: 10.3987/COM-12-12461
■ Expedient N-Arylation for the Synthesis of 2-Arylamino-3-cyanopyridines Using Ionic Copper(I) Complex as a Catalyst

Min Zhang,* Biao Xiong, Ting Wang, Xiaoting Wang, Fengxia Yan, and Yuqiang Ding*

*School of Chemistry and Materials Engineering, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu Province, 214122, China

Abstract

The N-arylation of 2-amino-3-cyanopyridines is firstly described by using ionic copper(I) complex (Phen)2Cu+BF4- (phen = 1,10-phenanthroline) as an efficient catalyst. The synthetic protocol can be applied to synthesize a wide range of 2-arylamino-3-cyanopyridine products in good to excellent isolated yields. The resulted products are potentially building blocks for further preparation of biologically interesting products or useful ligands for metal catalysis.