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Short Paper | Regular issue | Vol 85, No. 6, 2012, pp.1437-1446
Published online, 11th April, 2012
DOI: 10.3987/COM-12-12454
Identification of New Polyprenyl Hydroquinone Derivatives from Tropical Marine Sponge lrcinia Ircinia sp.

Hyi-Seung Lee,* Yeon-Ju Lee, Jong Wook Lee, Hee Jae Shin, Jong-Seok Lee, Kil-Nam Kim, Weon-Jong Yoon, Soo-Jin Heo, and Hye-Kyeong Kim*

*Marine Natural Products Laboratory, Korea Ocean Research & Development Institute, Ansan PO Box 29, Ansan 426-744, Korea


Chemical investigations of the tropical marine sponge of the genus Ircinia have resulted in the isolation of three new polyprenyl chromenes (13), together with known hydroquinone derivatives (49). Their structures were elucidated on the basis of mass spectrometry and detailed 2D NMR spectroscopic data. The anti-inflammatory activity of these compounds was evaluated. Compounds 7, 8, and 9 exhibited moderate inhibition of LPS-induced NO production in RAW 264.7 macrophages.