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Paper | Regular issue | Vol 85, No. 9, 2012, pp.2135-2145
Published online, 25th July, 2012
DOI: 10.3987/COM-12-12447
Methodology to Access Tetrahydrodipyridoimidazole Derivatives

Mohamed El Bousmaqui, Marion Donnier-Marechal, Paul-Emmanuel Larchanche, Patricia Melnyk, and Pascal Carato*

*Laboratorie de Chimie Thérapeutique, Faculté Pharmcie, Université de Lille 2, 3, rue du Professeur Laguesse, BP 83, 59006 Lille Cedex, France


While the synthesis of β and γ-carboline derivatives were well described in the literature, the preparation of their aza-analogs such as tetrahydrodipyridoimidazole derivatives were less explored. In our laboratory we developed various methods to access to these compounds using Bischler-Napieralski as well as Pictet-Spengler reactions.