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Short Paper | Regular issue | Vol 85, No. 5, 2012, pp.1155-1177
Published online, 23rd March, 2012
DOI: 10.3987/COM-12-12444
A Novel and Highly Efficient Protocol for the Synthesis of Chalcone Based 1,2-Diazepine and 1,2-Oxazepine Derivatives

B. Venkata Babu and Naseem Ahmed*

*Department of Chemistry, Indian Institute of Technology, Roorkee 247 667, Uttarakhand, India


A novel and highly efficient protocol is described for the synthesis of chalcone based 1,2-diazepine and 1,2-oxazepine derivatives. Under neat condition, the mixing and grinding of 1,5-diketones and hydrazine gave the cyclocondensation products in quantitative yields within 10-20 min at room temperature. Similarly, novel chalcone based 1,2-oxazepines were synthesized in excellent yields (85-88%) in 2-3 h at refluxed by the condensation of 1,5-diktones and hydroxylamine hydrochloride in water-ethanolic base.