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Short Paper | Regular issue | Vol 85, No. 4, 2012, pp.933-940
Published online, 8th March, 2012
DOI: 10.3987/COM-12-12440
■ Synthesis of Neoamphimedine

Shinsuke Nakahara,* Yoshio Mukai, and Akinori Kubo

*Meiji Pharmaceutical University, 2-552-1 Noshio, Kiyose, Tokyo 204-8588, Japan

Abstract

The synthesis of neoamphimedine (from Xestospongia sp.), which is a potent antitumor agent both in vitro and in vivo, also can induce topoisomerase II-mediated catenation of plasmid DNA in vitro. The synthesis was achieved in twelve steps from 2,5-dimethoxyphenethylamine in 6% overall yield.