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Short Paper | Regular issue | Vol 85, No. 4, 2012, pp.927-932
Published online, 21st February, 2012
DOI: 10.3987/COM-12-12438
New Type of Matrix for Analysis of Low Molecular Weight Compounds by MALDI-TOF MS

Masamichi Nakakoshi,* Natsumi Funakoshi, Hiroki Nakajima, and Masayoshi Tsubuki*

*Institute of Medicinal Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan


Matrix for analysis of low molecular weight compound by MALDI-TOF MS was investigated. We found the new type of matrix, 5-aryl-1H-tetrazoles, which are suitable for the detection of low molecular weight compound ions. When propranolol hydrochloride was measured with 5-aryl-1H-tetrazoles, the strong matrix-derived peaks are not detected in low mass range.