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Short Paper | Regular issue | Vol 85, No. 4, 2012, pp.919-925
Published online, 2nd March, 2012
DOI: 10.3987/COM-12-12435
■ A Facile Synthesis of 2-Arylthiochroman-4-ones by the Reaction of 3-Aryl-1-(2-halophenyl)prop-2-en-1-ones with Sodium Hydrogensulfide

Kazuhiro Kobayashi,* Akihiro Kobayashi, and Miyuki Tanmatsu

*Division of Applied Chemistry, Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan

Abstract

An efficient two-step procedure for the preparation of 2-arylthiochroman-4-ones has been developed. Thus, 3-aryl-1-(2-halophenyl)prop-2-en-1-ones, prepared by the condensation between 1-(2-halophenyl)ethanones and aromatic aldehydes in ethanol at room temperature, were treated with sodium hydrogensulfide in DMF at 80 ˚C to give 2-arylthiochroman-4-ones in good overall yields.