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Short Paper | Regular issue | Vol 85, No. 3, 2012, pp.689-696
Published online, 15th February, 2012
DOI: 10.3987/COM-12-12420
New Dihydroagarofuranoid Sesquiterpenes from Celastrus angulatus

Jiang-yun Liu, Bei-bei Tan, Xue-long Gong, Qiong-ming Xu,* Xiao-fei Sun, Pei-lie Cai, and Shi-lin Yang

*School of Pharmacy, Soochow University, Suzhou 215123, China

Abstract

Three new highly esterified β-dihydroagarofuran sesquiterpenes (1-3) were isolated from the root barks of Celastrus angulatus Max. together with eight (411) known ones. The new compounds were identified as 1β-picolinoyloxy-2β,6α-diacetoxy-8β,13-diisobutanoyloxy-9α-benzoyloxy-4α-hydroxy-β-dihydroagarofuran (1), 1β-picolinoyloxy-2β,6α-diacetoxy-8β,13-diisobutanoyloxy-9α-furanoyloxy-4α-hydroxy-β-dihydroagarofuran (2), and 1β,6α-diacetoxy-2β-nicotinoyloxy-8β,13-diisobutanoyloxy-9α-benzoyloxy-4α-hydroxy-β-dihydroagarofuran (3) on the basis of spectroscopic methods. Compounds 1-11 were all possessed cytotoxic activities against three human tumor cell lines by MTT assay.