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Review | Regular issue | Vol 85, No. 5, 2012, pp.993-1016
Published online, 12th March, 2012
DOI: 10.3987/REV-12-726
Synthesis of Nitrogen-Containing Heterocycles Using Conjugate Addition Reactions of Nucleophiles to α,β-Unsaturated Imines

Iwao Hachiya, Isao Mizota, and Makoto Shimizu*

*Department of Chemistry for Materials, Graduate School of Engineering, Mie University, 1577 Tsu, Mie 514-8507, Japan


Synthetic methods for the synthesis of nitrogen-containing heterocycles are of utmost interest and importance because these structures are the key components of natural and unnatural biologically active compounds and functionalized materials. This review summarizes the synthesis of nitrogen-containing heterocycles, where the conjugate addition of nucleophiles to α,β-unsaturated imines is the crucial step.