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Communication | Regular issue | Vol 83, No. 12, 2011, pp.2773-2778
Published online, 20th October, 2011
DOI: 10.3987/COM-11-12363
Efficient and Mild Procedure for the Decarboxylative Cyanomethyl Esterification of Arylmalonic Acids Using ClCH2CN/1,8-Diazabicyclo[5.4.0]undec-7-ene

Niiha Sasakura, Tomoyuki Yamauchi, Keiji Nakano, Yoshiyasu Ichikawa, and Hiyoshizo Kotsuki*

*Laboratory of Natural Products Chemistry, Faculty of Science, Kochi University, 2-5-1, Akebono-cho, Kochi 780-8520, Japan


An efficient and mild procedure for the decarboxylative cyanomethyl esterification of arylmalonic acids has been developed. The reaction can be performed at room temperature by using chloroacetonitrile and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in toluene, and the desired arylacetic acid cyanomethyl esters are obtained in high yields within a short period of time.