HETEROCYCLES

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

■ Efficient and Mild Procedure for the Decarboxylative Cyanomethyl Esterification of Arylmalonic Acids Using ClCH2CN/1,8-Diazabicyclo[5.4.0]undec-7-ene

Niiha Sasakura, Tomoyuki Yamauchi, Keiji Nakano, Yoshiyasu Ichikawa, and Hiyoshizo Kotsuki*

*Laboratory of Natural Products Chemistry, Faculty of Science, Kochi University, 2-5-1, Akebono-cho, Kochi 780-8520, Japan

Abstract

An efficient and mild procedure for the decarboxylative cyanomethyl esterification of arylmalonic acids has been developed. The reaction can be performed at room temperature by using chloroacetonitrile and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in toluene, and the desired arylacetic acid cyanomethyl esters are obtained in high yields within a short period of time.