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Short Paper | Regular issue | Vol 83, No. 12, 2011, pp.2851-2856
Published online, 11th October, 2011
DOI: 10.3987/COM-11-12343
Synthesis of N-(3-Cyano-7-ethoxy-1,4-dihydro-4-oxoquinolin-6-yl)acetamide

Qiang Zhang, Yongjun Mao, Zheng Liu, Kai Xie, Yi Zhu, Yabing Wei, Xiangrui Jiang,* and Jingshan Shen

*Chinese Academy of Sciences, Shanghai Institute of Materia Medica, 555 Zuchongzhi Rd., Zhangjiang Hi-Tech Park, Shanghai, 201203, China


New route for the preparation of N-(3-cyano-7-ethoxy-1,4- dihydro-4-oxoquinolin-6-yl)acetamide (1), a key intermediate for the synthesis of selective EGFR kinase inhibitors, was described.