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Paper | Regular issue | Vol 83, No. 11, 2011, pp.2535-2546
Published online, 27th September, 2011
DOI: 10.3987/COM-11-12331
Synthesis of Novel Methylene Bridge Functionalized Bis(indolyl)methanes through a Double Michael Addition

Mojgan Kargar, Rahim Hekmatshoar,* and AbdolJalil Mostashari

*Department of Chemistry, School of Sciences, Alzahra University, Vanak, Tehran, Iran


A simple synthesis of a series of novel diethyl bis(indol-3-yl)methylmalonate is described. This involves domino Michael addition/ elimination/Michael addition of indoles to diethyl ethoxymethylenemalonate as double Michael acceptor.