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Short Paper | Regular issue | Vol 83, No. 11, 2011, pp.2607-2613
Published online, 14th September, 2011
DOI: 10.3987/COM-11-12326
Microwave-Assisted Synthesis and Bioactivity of Novel 2,2,4,5-Tetrasubstituted 3-Dichloroacetyl-1,3-oxazolidines

Ying Fu, Lei Yang, Fei Ye,* and Shuang Gao

*Department of Applied Chemistry, College of Sciences, Northeast Agricultural University, No.59 Mucai Street Harbin 150030, Heilongjiang, China


An efficient one-pot synthesis of 2,2,4,5-tetrasubstituted-3-dichloroacetyl-1,3-oxazolidines under microwave irradiation was developed. The intermediate oxazolidines were attained by the reaction of amino alcohol with aldehyde or ketone in refluxing benzene with microwave-assisted cycloaddition, and then the acylation followed with dichloroacetyl chloride and NaOH acting as the attaching acid agent. All the compounds were characterized by IR, 1H-NMR, 13C-NMR and elemental analysis. The preliminary biological test shows that these compounds could protect maize against injury caused by acetochlor to a certain extent.