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Paper | Regular issue | Vol 83, No. 9, 2011, pp.2137-2147
Published online, 20th July, 2011
DOI: 10.3987/COM-11-12287
Estrogen Receptor α/β Ligands Derived from Thalidomide

Tomomi Noguchi-Yachide,* Kazuyuki Sugita, and Yuichi Hashimoto

*Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan


We have developed a series of thalidomide-derived phthalimide-type estrogen receptor (ER) modulators with characteristic subtype (ERα/ERβ) selectivity, and investigated their structure-activity relationship for ER agonistic and antagonistic activities.