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Paper | Regular issue | Vol 83, No. 9, 2011, pp.2067-2077
Published online, 6th July, 2011
DOI: 10.3987/COM-11-12267
One-Pot Synthesis of Dihydropyrimidiones via Environmentally Friendly Enzyme-Catalyzed Biginelli Reaction

Wanmei Li, Guobin Zhou, Pengfei Zhang,* Yifeng Lai, and Shifu Xu

*Chemistry and Chemical Engineering, College of Material, Hangzhou Normal University, Hangzhou 310036, China


A novel enzyme-catalyzed Biginelli reaction of acetoacetate, aromatic aldehyde and urea (thiourea) was described. Great acceleration of the one-pot multicomponent reaction was observed by the aid of enzymes. Various dihydropyrimidiones were prepared in good yields under the conditions using trypsin from porcine pancreas as the catalyst.