HETEROCYCLES

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

■ One-Pot Synthesis of Dihydropyrimidiones via Environmentally Friendly Enzyme-Catalyzed Biginelli Reaction

Wanmei Li, Guobin Zhou, Pengfei Zhang,* Yifeng Lai, and Shifu Xu

*Chemistry and Chemical Engineering, College of Material, Hangzhou Normal University, Hangzhou 310036, China

Abstract

A novel enzyme-catalyzed Biginelli reaction of acetoacetate, aromatic aldehyde and urea (thiourea) was described. Great acceleration of the one-pot multicomponent reaction was observed by the aid of enzymes. Various dihydropyrimidiones were prepared in good yields under the conditions using trypsin from porcine pancreas as the catalyst.