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Short Paper | Regular issue | Vol 83, No. 8, 2011, pp.1897-1902
Published online, 23rd June, 2011
DOI: 10.3987/COM-11-12257
Two New Xanthone Glucosides from Swertia mussotii Franch

Lu Gao, Yongfu Zhou, Haiying Yan, Feiyan Huang, Rongrong Wen, and Ganpeng Li*

*Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650031, China


Two new xanthone glucosides, 1-O-β-D-glucopyranosyl-3,5,6-trimethoxy-xanthone (1), 1-O-[β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl]-3,5,6-trimethoxy-xanthone (2), were isolated from a EtOH extract of the overground parts of Swertia mussotii Franch,which is a traditional Tibet medicine. Their structures were elucidated by spectroscopic methods as well as by chemical studies. Compound 1 showed α-glucosidase inhibitory activity, while compound 2 showed DPP-IV (Dipeptidyl Peptidase IV) inhibitory activity.