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Short Paper | Regular issue | Vol 83, No. 8, 2011, pp.1843-1851
Published online, 23rd May, 2011
DOI: 10.3987/COM-11-12218
Synthesis of the Identical Linker Mode Twin-Drug Type C2-Symmetrical Molecules

Fumiko Fujisaki, Haruka Usami, Saya Nakashima, Shiomi Iwashita, Yurie Kurose, Nobuhiro Kashige, Fumio Miake, and Kunihiro Sumoto*

*Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan


In connection with our studies on antibacterial active compounds against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) strains, some molecular modifications were attempted. In this study, molecular transformations of aminoguanidines and related amines to the represented C2-symmetrical molecules (Aab, Bab, and Cab) were investigated. In addition, some C3-symmetrical compounds (Dab) were also prepared.