Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Short Paper | Regular issue | Vol 83, No. 6, 2011, pp.1405-1408
Published online, 7th April, 2011
DOI: 10.3987/COM-11-12204
Purinium Derivatives with Antitumor Activities from Heterostemma alatum Wight

Wen-Wei Fu, Chang-Heng Tan,* Peng-Yu Zhuang, Shu-Min Yang, Hong-Feng Luo, Jun-Jie Tan, Ping Liu, and Da-Yuan Zhu

*Department of Natural Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China


Heteromine I (1), a new purinium derivative, together with six known compounds, were isolated from the aerial parts of Heterostemma alatum Wight. The structure of 1 has been established as 2-methylamino-6-methoxy-7,9-dimethyl-8-purinone by means of spectroscopic analysis. Two puriniums, heteromines J (2) and K (3) were isolated as natural products for the first time. Heteromine D (4) showed strong cytotoxicity against HL-60 cell line with IC50 of 4.04 nmol/mL.