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Paper | Regular issue | Vol 83, No. 6, 2011, pp.1355-1361
Published online, 13th April, 2011
DOI: 10.3987/COM-11-12203
Convenient One-Pot Synthesis of 3-Aryl-2H-chromene-4-carbonitriles via a Tandem O-Alkylation-Knoevenagel Condensatioin

Yanhong Chen, Haoyue Xiang, Yuyuan Xie, and Chunhao Yang*

*State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Science, 555 Zu Chong Zhi Road, Shanghai 201203, China

Abstract

3-Aryl-2H-chromene-4-carbonitriles were synthesized through one-pot tandem reaction of easily available 2-(2-hydroxyphenyl)acetonitrile (1) and 2-bromo-1-arylethanones (2) under the condition of K2CO3/dioxane. These functionalized chromenes could be useful building-blocks for estrogen receptor ligands and other related heterocycles.