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Paper | Special issue | Vol 84, No. 2, 2012, pp.1089-1112
Published online, 15th September, 2011
DOI: 10.3987/COM-11-S(P)92
Applications of Multicomponent Assembly Processes to the Facile Syntheses of Diversely Functionalized Nitrogen Heterocycles

James R. Donald, Brett A. Granger, Simon Hardy, James J. Sahn, and Stephen F. Martin*

*Department of Chemistry and Biochemistry, The Texas Institute for Drug and Diagnostic Development, The University of Texas at Austin, Austin, Texas 78712-1074, U.S.A.


Several multicomponent assembly processes have been developed for the synthesis of intermediates that may be elaborated by a variety of cyclizations to generate a diverse array of highly functionalized heterocycles from readily-available starting materials. The overall approach enables the efficient preparation of libraries of small molecules derived from fused, privileged scaffolds.