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Short Paper | Regular issue | Vol 83, No. 6, 2011, pp.1385-1394
Published online, 13th April, 2011
DOI: 10.3987/COM-11-12189
Synthesis of 1-Deoxyeldecalcitol, a Biologically Interesting Analog of 1α,25-Dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (Eldecalcitol)

Hirotaka Sasaki, Kohei Eto, Keisuke Takahashi, Jun Ishihara, Susumi Hatakeyama, and Noboru Kubodera*

*Chugai Pharmaceutical Company, Ltd., 2-1-1, Nihonbashi-Muromachi, Chuo-ku, Tokyo 103-8324, Japan

Abstract

A synthesis of biologically interesting 1-deoxyeldecalcitol, a dehydroxylated analog at the 1α-position of 1α,25-dihydroxy-2β-(3-hydroxy- propoxy)vitamin D3 (eldecalcitol), using Trost’s coupling methodology is described.