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Short Paper | Regular issue | Vol 83, No. 6, 2011, pp.1371-1376
Published online, 14th April, 2011
DOI: 10.3987/COM-11-12176
An Efficient Arylation of Benzoazoles with Aryl Bromides by a Practical Palladium-Copper Cocatalytic System

Xue-Ming Yan, Xue-Rong Mao, and Zhi-Zhen Huang*

*School of Chemistry and Chemical Engineering , Nanjing University, Nanjing 210093, China


A practical, efficient Pd(OAc)2/Cu(II)/PPh3 cocatalytic system has been developed. With only 1 mol% Pd(OAc)2, 20 mol% copper(II) salt, and 0.5 equiv of inexpensive PPh3 as ligand, the direct arylation of benzoazoles with aryl bromides could be performed smoothly in mild condition, affording the desired arylated benzoazoles in good yields (75-93%).