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Communication | Regular issue | Vol 83, No. 5, 2011, pp.1005-1012
Published online, 10th March, 2011
DOI: 10.3987/COM-11-12147
Synthesis of Various Substituted Spiro- and Bicyclethiazolidine-2-thiones by a Multicomponent Reaction and Biological Evaluation in vitro

Xiao-Juan Wang, Hai-Wei Xu, Lin-Lin Guo, En Zhang, Guang-Wei Chen, Xiao Guo, and Hong-Min Liu*

*New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450002, China


A series of novel spiro[4.4] and bicycle[3.3.0]-N-substituted thiazolidine-2-thiones were obtained by a multicomponent reaction under mild conditions. Each of the synthesized compounds was evaluated for their cytotoxic activity and antibacterial activity. Some of them exhibited significantly inhibited proliferation of human tumor cell lines and moderate inhibitory effect on fungi.