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Short Paper | Regular issue | Vol 83, No. 3, 2011, pp.631-636
Published online, 8th February, 2011
DOI: 10.3987/COM-10-12126
■ Phloroglucinols from the Leaves of Eucalyptus globulus

Tetsuro Kawabata, Tatsuya Hasegawa, Yuka Nojiri, Chiaki Uchida, Tomoyuki Tsubata, Hikaru Kato, Fumihide Takano, and Tomihisa Ohta*

*Department of Pharmacognosy and Chemistry of Natural Products, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, Ishikawa 920-1192, Japan

Abstract

A new acylphloroglucinol sesquiterpene structure, euglobal-IX (1), together with five known compounds, euglobal-III (2), -IVa (3), -IVb (4), -Ia2 (5) and robustadial B (6), were isolated from the leaves of Eucalyptus globulus extracted with methanol or methanolic ethylacetate. The chemical structure and relative configuration of 1 was determined by 1D, 2D NMR and MS spectroscopic analyses. New acylphloroglucinol 1 inhibited the catalytic activity of CYP3A4 (IC50 = 38.8 μM).