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Short Paper | Regular issue | Vol 83, No. 3, 2011, pp.609-617
Published online, 14th January, 2011
DOI: 10.3987/COM-10-12104
■ Synthesis and Antimicrobial Evaluation of Some New Tetrahydropyrimidine Derivatives

Yahia N. Mabkhot, Nabila A. Kheder,* and Ahmad M. Farag

*Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt

Abstract

The utility of 1,2,3,4-tetrahydropyrimidine-5-carboxylate (1a,b), and 1,2-dihydropyrimidine-5-carboxylate (2) in the synthesis of some new functionalized pyrimidine derivatives such as 6-(2-(dimethylamino)vinyl)-1,2,3,4-tetrahydropyrimidine, 6-(1-cyano-2-(phenylamino)-2-thioxoethyl)-1,2,3,4-tetra-hydropyrimidine and 4,6-distyryl-1,2-dihydropyrimidine derivatives is reported. Antimicrobial evaluation of some selected examples from the synthesized products was carried out and showed promising results.