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Review | Regular issue | Vol 83, No. 4, 2011, pp.695-738
Published online, 24th December, 2010
DOI: 10.3987/REV-10-687
■ Synthetic Routes towards Thiazolo[1,3,5]triazines (Review)

Anton V. Dolzhenko*

*School of Pharmacy, Curtin University of Technology, GPO Box U1987, Perth, Western Australia 6845, Australia

Abstract

The present review summarizes information on the synthetic approaches to thiazolo[3,2-a][1,3,5]triazines and polyfused systems bearing this heterocyclic core since the first report on this structure in 1887. The methods allowing access to the heterocyclic systems comprising isomeric thiazolo[3,4-a][1,3,5]triazine scaffold are also included in the review. Data concerning potential applications of the thiazolo[1,3,5]triazines, particularly as biologically active agents are discussed.