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Short Paper | Regular issue | Vol 83, No. 1, 2011, pp.125-134
Published online, 24th November, 2010
DOI: 10.3987/COM-10-12079
Synthesis of Fluoroquinolone-di- and tri-(N-methylpyrrole) Conjugates

Ichiro Suzuki,* Mayuko Takahashi, and Kei Takeda

*Divison of Medicinal Chemisry, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan


Some FLQs, such as lomefloxacin and fleroxacin, having two fluorine atoms are known to generate an arylcarbene under photoirradiation conditions leading to DNA damage. We synthesized some conjugates between FLQs and di- and tri-(N-methylpyrrole) that are known as a DNA minor groove binder.