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Note | Regular issue | Vol 81, No. 12, 2010, pp.2865-2872
Published online, 9th November, 2010
DOI: 10.3987/COM-10-12070
■ Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels

Luca Piemontese, Giuseppe Carbonara, Giuseppe Fracchiolla, Antonio Laghezza, Paolo Tortorella, and Fulvio Loiodice*

*Medicinal Chemistry Department, University of Bari “Aldo Moro”, via E. Orabona, 4, 70126, Bari, Italy

Abstract

Improved experimental conditions were carried out for the preparation in high yields of some 3-phenyl-1-benzofuran-2-carboxylic acids, potent inhibitors of ClC-K chloride channels. A one-pot condensation-cyclization was set up starting from different 2-hydroxybenzophenones whose reactivity was significantly affected from the electronic properties of their substituents.