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Note | Regular issue | Vol 81, No. 12, 2010, pp.2849-2854
Published online, 4th November, 2010
DOI: 10.3987/COM-10-12067
A Rapid and High-Yielding Synthesis of Thiazoles and Aminothiazoles Using Tetrabutylammonium Salts

Erdal Kocabas,* Ahmet Burak Sarıguney, and Ahmet Coskun

*Department of ChemistryM, Selcuk University, Meram 42009, Konya, Turkey

Abstract

A convenient method for the synthesis of thiazoles and aminothiazoles by treatment of phenacyl bromides with thioamides/thiourea in the presence of tetrabutylammonium hexafluorophosphate (Bu4NPF6) at room temperature was developed. The products having high yields were formed rapidly (within 15 min). The method is simple, rapid and practical, generating thiazole derivatives in excellent isolated yields. The structures of the newly synthesized products were identified by FT-IR, 1H NMR, 13C NMR spectroscopy and elemental analysis data.