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Review | Regular issue | Vol 81, No. 11, 2010, pp.2439-2463
Published online, 1st October, 2010
DOI: 10.3987/REV-10-678
Selenium-Containing Bicyclic β-Lactams

Dinesh R. Garud, Masayuki Ninomiya, and Mamoru Koketsu*

*Department of Materials Science and Technology, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan


The first β-lactam ring system was synthesized by H. Staudinger in 1907, but β-lactams as a class of compounds became attractive only after it was established that penicillin contained a β-lactam unit as the structural feature. Over the years, countless numbers of penicillin derivatives and a variety of new β-lactam ring systems have been prepared, tested, and introduced. As a class of β-lactam derivatives, selenium-containing bicyclic β-lactams have received only a limited attention. In this review the advances in the development of synthesis methods for selenium-containing bicyclic β-lactams are presented and discussed.