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Note | Regular issue | Vol 81, No. 10, 2010, pp.2377-2384
Published online, 26th August, 2010
DOI: 10.3987/COM-10-12034
New Prenylated Xanthone from the Branch of Garcinia costata

Warraphong Nuangnaowarat, Worrapong Phupong,* Kamolphan Intereya, and Masahiko Isaka

*School of Science, Walailak University, Thaiburi, Thasala, Nakhon Si Thammarat 80161, Thailand

Abstract

A new triprenylated xanthone, costatin (1), together with five known xanthones (2-6), was isolated from a branch of Garcinia costata (Guttiferae). The structure was elucidated on the basis of spectroscopic data. All xanthone derivatives were evaluated for antimalarial, anti-tuberculosis (TB), cytotoxicity against human breast adenocarcinoma cell line (MCF-7), anti-human KB-cell line and cytotoxicity against African green monkey kidney (Vero) cells. Costatin (1) exhibited significant antimalarial activity (IC50 1.57 μg/mL); however, it also showed comparable cytotoxic activity (IC50 1.12 μg/mL).