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Short Paper | Regular issue | Vol 83, No. 1, 2011, pp.91-97
Published online, 19th November, 2010
DOI: 10.3987/COM-10-12026
Synthesis of Novel 5-(Pyrimidin-5-yl)-1,2,4-oxadiazole Derivatives via a Three-Component Cycloaddition and Subsequent Oxidative Dehydrogenation

Tong-Hui Huang, Hai-Yang Tu,* Ming Liu, and Ai-Dong Zhang*

*Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China


A new and efficient strategy has been developed for the synthesis of novel 5-(pyrimidin-5-yl)-1,2,4-oxadiazoles with a wide diversity in substituents via Biginelli cycloaddition and subsequent oxidative dehydrogenation.